Macrophage-Derived Compound to Treat Autoimmune Disorders

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Macrophage-Derived Compound to Treat Autoimmune Disorders Metabolic regulation has been recognized as a powerful principle guiding immune responses. Inflammatory macrophages undergo extensive metabolic rewiring marked by the production of substantial amounts of itaconate, which has recently been described as an immunoregulatory metabolite. Itaconate and its membrane-permeable derivative dimethyl itaconate (DI) selectively inhibit a subset of cytokines, […]

The post Macrophage-Derived Compound to Treat Autoimmune Disorders appeared first on BioTecNika .Read more at www.biotecnika.org/2018/04/macrophage-derived-compound-to-treat-autoimmune-disorders/

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